C. Delacroix

Inhibition of integrin alpha V (CD51) reduces inflammation and transition to heart failure following pressure overload

This study shows that inhibiting integrin alpha V reduces inflammation and prevents heart failure progression in pressure-overloaded mice by modulating pro-inflammatory macrophages.

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle

This study shows that Prox1 gene transfer reduces muscle fragility in exercised dystrophic mdx mice but not sedentary ones, suggesting a synergistic effect with chronic exercise.

Desmin is a modifier of dystrophic muscle features in Mdx mice

This study shows that desmin deletion in Mdx mice worsens muscle weakness, fragility, and fatigue resistance, while desmin gene transfer improves these features.