F. Dyda

Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa

This study identifies the molecular mechanisms by which CifR, an epoxide-sensing transcriptional repressor, regulates the virulence gene cif in Pseudomonas aeruginosa.

Toxic anti-phage defense proteins inhibited by intragenic antitoxin proteins

The paper identifies Rpn proteins as toxin-antitoxin systems that inhibit phage infection by blocking toxic full-length proteins with their smaller, variable C-terminal domains.

Formation of the active Hermes transpososome is driven by asymmetric DNA binding of BED domains

The paper investigates how the Hermes transposase forms an active tetramer and shows that it binds asymmetrically to the transposon ends, with stronger interaction at the left-end through BED domains.