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Discovery and heterologous expression of functional 4-O-dimethylallyl-L-tyrosine synthases from lichen-forming fungi.

The paper identifies and expresses two functional 4-O-dimethylallyl-L-tyrosine synthases from lichen-forming fungi, revealing their substrate specificity and potential for biocatalytic applications.

Ribonanza: deep learning of RNA structure through dual crowdsourcing

The paper introduces RibonanzaNet, a deep learning model trained on crowdsourced RNA chemical mapping data to predict RNA structure and related properties.

Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance in AML

This study identifies four transcriptionally distinct venetoclax-resistant clusters in AML, revealing phenotypic, genetic, and drug response differences and their implications for treatment resistance.

Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome

This paper creates a vascular organoid model with an AKT1 mutation to study Proteus syndrome and finds AKT inhibitors reverse vascular malformations.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa

This study identifies the molecular mechanisms by which CifR, an epoxide-sensing transcriptional repressor, regulates the virulence gene cif in Pseudomonas aeruginosa.

A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions

This paper uses a BRET-based high-throughput screen to identify FDA-approved drugs that disrupt 14-3-3{zeta}BAD interactions, showing potential for colorectal cancer treatment.

Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis

This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.

RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

Combining Bulk and Single-Cell RNA Sequencing Data to Identify RNA methylation and Autophagy-Related Signatures in Patients with Chronic Obstructive Pulmonary Disease

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

African bush pigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

Metabolomics-assisted mechanism analysis of gamma-PGA synthesis regulated by PhoP in B. licheniformis

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

Viral impacts on microbial activity and biogeochemical cycling in a seasonally anoxic freshwater lake

The paper examines how seasonal anoxia affects viral and microbial biogeochemical cycling in a freshwater lake using metagenomic and metatranscriptomic data.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

This study investigates how zinc affects the structure and function of TIA1 nucleic acid complexes, showing zinc induces conformational changes and reduces nucleic acid accessibility.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning in Nematostella vectensis

This study uses spatial transcriptomics to identify conserved segment polarity genes in Nematostella vectensis, suggesting polarized metameric structures existed in the Cnidaria-Bilateria common ancestor.

Focused ultrasound-mediated brain genome editing

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

miR-29 is an important driver of aging-related phenotypes

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

A robotic system for automated genetic manipulation and analysis of Caenorhabditis elegans

This paper introduces a robotic system for automated genetic manipulation of C. elegans, demonstrating reliability and throughput comparable to manual methods.

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs

This study shows that the rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs, while the rVSV-SUDV vaccine offers complete protection.

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors

This study identifies XPO1 inhibitors as selective killers of TET2-mutant HSPCs and AML cells through apoptosis, without DNA damage.

Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids

This study engineers a plant enzyme to increase the production of methylated flavonoids in engineered microbes.

Signatures of Microbial Diversity at Multiple Scales of Resolution within Engineered Enrichment Communities

The paper examines microbial diversity signatures in lab-scale and full-scale phosphorus removal communities across multiple phylogenetic scales.

An Immune Cell Recirculation-Enabled Microfluidic Array to Study Dynamic Immunotherapeutic Activity in Recapitulated Tumor Microenvironment

The paper develops a microfluidic array to study immune cell interactions in a tumor microenvironment, showing that anti-PD-L1 treatment improves T cell infiltration and reduces cancer cell apoptosis.

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

This study identifies STAT3's role in driving MYC expression and oncogenesis in ALCL by cooperating with a core transcriptional regulatory circuit.

A reductase in the lipid metabolism at cross roads between cuticular wax production and jasmonic acid-mediated defenses in maize

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.