X. Jiang

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Single-molecule live-cell RNA imaging with CRISPR-Csm

This paper introduces smLiveFISH, a method for single-molecule live-cell imaging of endogenous RNA using CRISPR-Csm, and identifies two distinct mRNA localization mechanisms.

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

Transcranial Photobiomodulation on the Left Prefrontal Cortex Enhances Mandarin Chinese L1 and L2 Complex Sentence Processing Performances

This study shows that transcranial photobiomodulation over the left prefrontal cortex improves sentence processing in Mandarin Chinese L1 and L2 speakers without affecting working memory.

Genomic and transcriptomic characteristics of type VI secretion system in Klebsiella pneumoniae

This study analyzes the genomic and transcriptomic features of the Type VI secretion system (T6SS) in Klebsiella pneumoniae, showing its presence in all clinical isolates and its role in interbacterial competition.

Emergence of synchronised growth oscillations in filamentous fungi

This study observes synchronized growth oscillations in Serendipita indica fungi during sporulation using a microfluidic setup and links it to cell-cell communication.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2

This study identifies and characterizes the biosynthetic pathway for azodyrecin, an azoxy compound produced by Streptomyces mirabilis P8-A2, revealing key enzymes and gene cluster distribution across Streptomyces species.

Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

The paper examines how human disturbance affects spatiotemporal associations among mountain forest terrestrial mammals using camera-trap data from the eastern Himalaya.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Topoisomerase IIα C-terminal Domain Mutations and Catalytic Function

This study examines how mutations in the C-terminal domain of Topoisomerase IIα affect clamp closure and DNA cleavage, finding that some mutants show reduced activity and that Cu-APY-ETSC impacts DNA cleavage similarly to wild-type enzyme.

Artificial Intelligence Helps to Predict Recurrence and Mortality for Prostate Cancer using Histology Images

This study develops an AI system to predict prostate cancer recurrence using histology images, showing it outperforms existing grading systems in risk categorization.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

Quantification of glutathione with high throughput live-cell imaging

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezualen Equine Encephalitis virus within olfactory sensory neurons

This study shows that intranasal IFNα treatment suppresses VEEV replication and neuroinvasion in olfactory sensory neurons, improving survival and delaying encephalitis onset in mice.

Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursors

This study identifies functionally and metabolically distinct melanoma-associated macrophages originating from common bone-marrow precursors, with implications for targeted therapy.

Genomic and transcriptomic analysis revealed new insights into the influence of key T6SS genes hcp and vgrG on drug resistance and interbacterial competition in Klebsiella pneumoniae

Ex-Lactobacillus Strains with Intrinsic Propensity to Stabilize Pickering Oil-in-Water Emulsions

The paper evaluates surface characteristics of ex-Lactobacillus strains to identify those with intrinsic potential as Pickering emulsion stabilizers, finding that 4 strains show strong droplet size stability.

Toxic anti-phage defense proteins inhibited by intragenic antitoxin proteins

The paper identifies Rpn proteins as toxin-antitoxin systems that inhibit phage infection by blocking toxic full-length proteins with their smaller, variable C-terminal domains.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Mitochondrial genome evolution in the Diprionidae: Major gene rearrangement in the basal Hymenoptera

The paper examines mitochondrial gene rearrangements in Diprionidae, showing their potential as phylogenetic markers in Hymenoptera evolution.

The Mechanism underlying B cell Developmental Dysfunction in Kawasaki Disease Based on Single-cell Transcriptomic Sequencing

This study uses single-cell transcriptomics to identify B cell developmental dysfunction in Kawasaki Disease, showing repression of immune processes and altered gene expression in HSPCs and B cells before treatment.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.