Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cells.
F. Fabro, T. V. Kers, K. J. Feller, C. Beerens, I. Ntafoulis, A. Idbaih, M. Verrault, K. Connor, A. Biswas, M. Salvucci, J. H. M. Prehn, A. T. Byrne, A. C. O'Farrell, D. Lambrechts, G. Dilcan, , S. Leenstra
This study identifies two molecular phenotypes, ADA and N-ADA, associated with temozolomide resistance in glioblastoma cells through bulk and single-cell RNA sequencing.
bioRxiv · Aug 11, 2023Cancer Biology