J. H. M. Prehn

This paper identifies four microbial subtypes in colorectal cancer tumours and adjacent mucosa, linking them to clinical and molecular features and demonstrating prognostic value.

This study identifies Bcl-xL as a mediator of resistance to KRASG12C inhibitors in colorectal cancer and shows that combining Bcl-xL inhibition with KRASG12C inhibition enhances apoptosis and reduces tumor growth.

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

The paper develops a method to profile N-respirasomes at single-cell resolution and identifies CHCHD3's role in regulating them, revealing mitochondrial bioenergetic abnormalities.

This study identifies TRAIL as a promoter of entosis in colorectal cancer cells and links CICs to poor patient prognosis.