A. Biswas

Projections between the globus pallidus externa and cortex span motor and non-motor regions

The paper identifies two distinct electrophysiological and molecular phenotypes of pallidocortical neurons projecting to motor and non-motor cortical regions, revealing a closed-loop circuit between the GPe and cortex.

Cell State-Specific Cytoplasmic Material Properties Control Spindle Architecture and Scaling

The paper investigates how cytoplasmic density changes during cell differentiation and how this affects mitotic spindle architecture and scaling.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Simulations reveal unique roles for the FXR hinge in the FXR-RXR nuclear receptor heterodimer

The paper uses simulations to study the FXR-RXR heterodimer's structure and shows the hinge's role in DNA binding and interdomain allostery.

The Hidden Potential of PDE4 Inhibitor Rolipram: A Multifaceted Examination of its Inhibition of MMP2/9 Reveals Therapeutic Implications

This paper investigates rolipram's inhibition of MMP2/9 beyond its PDE4 activity, showing it affects MMP enzymatic activity and stability through direct protein binding.

Globetrotting geckos: Historical biogeography suggests an Indian origin and an ''Out-Of-India'' dispersal for the cosmopolitan Hemidactylus geckos

This study reconstructs the biogeographic history of Hemidactylus geckos, finding an Indian origin and multiple dispersals from India to Africa and Asia.

PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

Rolipram inhibits hedgehog signaling by promoting ubiquitination and degradation of GLI2FL and GLI3FL, reducing GLI1 levels and tumor growth in breast cancer models.

Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas syringae and Pseudomonas savastanoi

This study tests evolutionary forecasts in related bacterial species under similar conditions, showing that phenotypes are predictable but molecular details are not.

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

Elucidating the molecular determinants for binding modes of a third-generation HIV-1 integrase strand transfer inhibitor: Importance of side chain and solvent reorganization

This study identifies molecular determinants of binding modes for a third-generation HIV-1 integrase inhibitor, showing that side chain and solvent reorganization, along with conformational entropy, influence ligand binding preferences in closely related viral intasomes.

Tyrosine halogenation converts α-defensins into potent immunomodulators

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes

This study shows that the nuclear-to-cytoplasmic density ratio is conserved across eukaryotes and drives cellular organization, with implications for diseases like cancer and senescence.

Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cells.

This study identifies two molecular phenotypes, ADA and N-ADA, associated with temozolomide resistance in glioblastoma cells through bulk and single-cell RNA sequencing.

A conformationally constrained synthetic peptide efficiently inhibits malaria parasite entry into human red blood cells

The paper describes a synthetic cyclic peptide that inhibits malaria parasite entry into human red blood cells by enhancing receptor binding affinity.

Formation of clathrin-pits and ATP-independent cholesterol-dependent tubules initiates mechano-regulation on de-adhesion.

This study shows that during de-adhesion, cells use endocytosis to regulate membrane fluctuations, with dynamin-dependent and cholesterol-dependent ATP-independent mechanisms contributing.

Non-canonically regulated heterochronic expression of Hsp70 drives clonal expansion and invasion in Drosophila epithelial tumors

This study shows that non-canonical Hsp70 regulation via ROS-JNK-FOXO pathway drives clonal expansion and invasion in Drosophila epithelial tumors.

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressure

This paper uses kinetic co-evolutionary models to predict the temporal emergence of HIV resistance mutations under drug selection pressure, showing that epistasis determines DRM acquisition rates.

Calcitic prisms of the giant seashell Pinna nobilis form light guide arrays

This study shows that the prismatic layer of Pinna nobilis shells functions as light guides, enhancing optical resolution and contrast for tracking movement.

Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

The paper investigates how FG motif identity and inter-FG spacer length affect the barrier properties of Nup98 FG phases, showing their role in nuclear transport selectivity.

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.

This study identifies key residues in eIF6 and RPL23 that mediate their interaction and shows how mutations in SDS disrupt this interaction, offering a therapeutic target for cancer and SDS.

Group 3 Innate Lymphoid Cells are regulated by WASP in a microbiota-dependent manner

This study shows that WASP is essential for ILC3 development and function in the presence of commensal bacteria, with reduced ILC3s and increased susceptibility to infection in WASP-deficient mice.

RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress

This study identifies Scd6/LSM14A proteins as regulators of mRNA translation during hydroxyurea-induced genotoxic stress, showing their role in modulating SRS2 and NHEJ factor mRNAs through arginine methylation.

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

This study identifies six cysteines in HEV ORF1 critical for viral replication through divalent cation coordination, revealing domain-domain interactions essential for structure and function.

KMT2C deficiency promotes APOBEC mutagenesis and genomic instability in multiple cancers

This study shows KMT2C deficiency increases APOBEC mutagenesis and genomic instability in multiple cancers by impairing DNA replication and promoting APOBEC activity.

Trimeric Photosystem I facilitates energy transfer from phycobilisomes in Synechocystis sp. PCC 6803

Cyanobacterial mutants with monomeric PSI show changes in the composition and abundance of phycobilisomes and in the excitation energy transfer to PSII and PSI.

Computational and experimental studies of the breathing motion of a protein loop: implications in PfAMA1-PfRON2 late-stage binding event

This study combines computational simulations and experimental assays to investigate how the domain II loop of PfAMA1 influences the binding kinetics of PfRON2, identifying key residues critical for the interaction.

A Chimeric Peptide Inhibits Red Blood Cell Invasion by Plasmodium falciparum with Hundredfold Increased Efficacy

The paper designs a chimeric peptide that inhibits Plasmodium falciparum red blood cell invasion with 100x higher efficacy than its parent peptides.

High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems

The paper examines the relationship between viral abundance and diversity and CRISPR-Cas prevalence across microbial ecosystems using metagenomic data.

The role of epistasis in determining the fitness landscape of HIV proteins

This paper investigates epistasis in HIV proteins, showing strong evidence for long-range epistasis through sequence models but weak evidence from experimental fitness measures.