Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency
G. Milardi, B. Di Lorenzo, J. Gerosa, F. Barzaghi, G. Di Matteo, M. Omrani, T. Jofra, I. Merelli, M. Barcella, F. Ferrua, F. P. Giuffrida, F. Dionisio, P. Rovere-Querini, S. Marktel, A. Assanelli, , C. Cancrini
The paper identifies a subset of CVID patients with Tfh cells showing replicative exhaustion, apoptosis, and senescence linked to DNA repair and telomere elongation defects.
bioRxiv · Jun 15, 2021Immunology