XLID Syndrome Gene Med12 Promotes Ig Isotype Switching through Chromatin Modification and Enhancer RNA regulation
F. Haque, T. Honjo, N. A. Begum
This study shows Med12 promotes Ig isotype switching by regulating chromatin modification and enhancer RNA at the IgH 3RR region, with implications for X-linked intellectual disability.
bioRxiv · Jun 14, 2022Immunology