E. J. Nelson

Phage predation, disease severity and pathogen genetic diversity in cholera patients

A study of cholera patients in Bangladesh identifies phage predation as a biomarker of disease severity and driver of coevolution within patients.

Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

This study develops a monoclonal antibody to the vibriophage ICP1 to improve cholera detection in rapid diagnostic tests by detecting the phage as a proxy for Vibrio cholerae.

Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions

This study shows that antimicrobial resistance in Vibrio cholerae increases under anaerobic conditions and identifies distinct genetic factors associated with resistance in these conditions.

Bacteroides thetaiotaomicron-infecting bacteriophage isolates inform sequence-based host range prediction

The paper isolates and analyzes 27 bacteriophages infecting Bacteroides thetaiotaomicron, identifies phage structural gene alleles linked to infectivity, and highlights unexplored phage diversity in the human gut.

Gold-standard diagnostics are tarnished by lytic bacteriophage

This study shows that lytic bacteriophage and antibiotic exposure reduce diagnostic positivity for cholera, suggesting that current diagnostic methods may underestimate cholera burden.