Activation of the endoplasmic reticulum unfolded protein response reverses an inflammation-like response to cytoplasmic DNA
A. Williams, F. Heider, J.-E. Messling, W. Bloch, B. Schumacher
The paper shows that in C. elegans, persistent cytoplasmic DNA causes tissue degeneration through impaired protein homeostasis, which can be reversed by activating the UPRER or using N-acetylglucosamine.
bioRxiv · Oct 11, 2018Cell Biology