The NF-κB pathway regulates heterochromatin at intronic young LINE-1 elements and hematopoietic stem cell gene expression during irradiation stress
Y. Pelinski, D. Hidaoui, A. Stolz, F. Hermetet, R. Chelbi, M. K. Diop, A. Chioukh, F. Porteu, E. Elvira-Matelot
The paper shows that ionizing radiation induces H3K9me3 loss at intronic L1Md retroelements, linked to NF-κB repression and HSC gene expression changes.
bioRxiv · Jun 8, 2021Cell Biology