Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov
The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.
bioRxiv · Oct 5, 2023 · PreprintBiochemistry
R. Berkane, H. Ho-Xuan, M. Glogger, P. Sanz-Martinez, L. Brunello, T. Glaesner, S. K. Kuncha, K. Holzhueter, S. Cano-Franco, V. Buonomo, P. Cabrerizo-Poveda, A. Balakrishnan, M. Misra, T. Juretschke, K. Husnjak, , A. Stolz
This study identifies CK2-dependent phosphorylation and ubiquitination as essential for FAM134B and FAM134C-driven ER-phagy activation during mTOR inhibition.
bioRxiv · Feb 27, 2023Cell Biology
L. Yoon, R. C. Botham, A. Verhelle, Y. Wu, C. Cole, E. P. Tan, L. A. Massey, P. Sanz-Martinez, C. C. Chou, J. Xu, L. P. Elia, K. Lee, S. R. Labra, G. M. Kline, Q. Xiao, , S. Encalada
The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.
bioRxiv · Sep 29, 2022 · PreprintCell Biology
Y. Pelinski, D. Hidaoui, A. Stolz, F. Hermetet, R. Chelbi, M. K. Diop, A. Chioukh, F. Porteu, E. Elvira-Matelot
The paper shows that ionizing radiation induces H3K9me3 loss at intronic L1Md retroelements, linked to NF-κB repression and HSC gene expression changes.
bioRxiv · Jun 8, 2021Cell Biology
C. I. Wells, H. Al-Ali, D. M. Andrews, C. R. M. Asquith, A. D. Axtman, M. Chung, I. Dikic, D. Ebner, J. Elkins, P. Ettmayer, C. Fischer, M. Frederiksen, N. S. Gray, S. B. Hatch, S. Knapp, , D. H. Drewry
The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.
bioRxiv · Dec 22, 2019Cell Biology
H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday
This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.
bioRxiv · Sep 5, 2019 · PreprintCancer Biology
A. Chaikuad, S. E. Koschade, A. Stolz, K. Zivkovic, S. Shaid, C. Pohl, H. Ren, L. J. Lambert, N. D. P. Cosford, C. H. Brandts, S. Knapp
The paper presents the crystal structure of ULK2 with ATP inhibitors, identifies off-target effects of ULK1 inhibitors, and suggests structural insights for developing dual ULK1/2 inhibitors.
bioRxiv · Feb 14, 2019Biochemistry
V. V. Rogov, A. Stolz, A. C. Ravicahandran, A. Law, H. Suzuki, A. Kniss, D. O. Rios-Szwed, F. Loehr, S. Wakatsuki, V. Doetsch, I. Dikic, R. C. J. Dobson, D. McEwan
The paper identifies a GABARAP-specific interaction motif (GIM) and demonstrates its selectivity over LC3 using biophysical and structural analyses.
The EMBO Reports · Aug 1, 2017Peer-reviewedBiochemistry