Author

F. Horns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Research Focus:clustering· 3 Organism:human· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. L. Dekker· 2 shared S. R. Quake· 2 shared C. S. McGinnis· 1 shared C. Vollmers· 1 shared D. M. Patterson· 1 shared D. Yang· 1 shared E. D. Chow· 1 shared J. J. Quinn· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

C. L. Dekker

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Author profile →

4 papers

Recent·Most cited

Fate Bias and Transcriptional Memory of human B cells

M. Swift, F. Horns, S. Quake

This study uses single-cell transcriptomics and lineage tracing to show that human B cell subtypes have intrinsic proliferative and fate biases, with transcriptional memory persisting in genes related to fate determination.

bioRxiv · Jul 14, 2022Immunology

Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

D. Yang, M. G. Jones, S. Naranjo, W. M. Rideout, K. H. J. Min, R. Ho, W. Wu, J. M. Replogle, J. L. Page, J. J. Quinn, F. Horns, X. Qiu, M. Z. Chen, W. A. Freed-Pastor, C. S. McGinnis, , J. S. Weissman

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

bioRxiv · Oct 12, 2021 · PreprintCancer Biology

Transcriptional program of memory B cell activation, broadly binding anti-influenza antibodies, and bystander activation after vaccination revealed by single-cell transcriptomics

F. Horns, C. L. Dekker, S. R. Quake

This study uses single-cell transcriptomics to analyze memory B cell activation, antibody production, and bystander activation after influenza vaccination, revealing transcriptional programs and clonal dynamics.

bioRxiv · Jul 22, 2019Immunology

Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral Drift

F. Horns, C. Vollmers, C. L. Dekker, S. R. Quake

The paper identifies molecular signatures of evolutionary processes in human antibody repertoires, showing how selective sweeps, competing subclones, and neutral drift shape antibody diversity.

bioRxiv · Oct 19, 2017Immunology