X. Qiu

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome

This study links affective symptoms during pregnancy to vaginal microbiome composition, showing associations with specific taxa and metabolic pathways.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

Graph-Dynamo: Learning stochastic cellular state transition dynamics from single cell data

This paper introduces Graph-Dynamo, a framework that learns stochastic cellular state transition dynamics from single cell data using graph-based methods and Fokker-Planck equations.

Mitochondrial proteostasis mediated by CRL5Ozz and Alix maintains skeletal muscle function

This study identifies CRL5Ozz and Alix as regulators of mitochondrial proteostasis by controlling Slc25A4 levels, which impacts mitochondrial function and muscle fiber composition.

Sequence-dependent orientational coupling and electrostatic attraction in cation-mediated DNA-DNA interactions

This study elucidates DNA condensation mechanisms by analyzing cation dynamics and sequence-dependent interactions under different salt conditions.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration

This study identifies TGFB1 as a key driver of fetal reprogramming and intestinal regeneration, showing its role in enhancing epithelial repair through a YAP-SOX9 transcriptional circuit.

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

This study identifies RELMα's role in sex-specific obesity protection by regulating adipose macrophages and eosinophils, revealing a therapeutic target for obesity.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

Targeting TR4-induced RCC cells-derived exosomally initiated signaling increases Sunitinib efficacy

This study shows TR4 promotes RCC cell-derived exosomal ADAM15, which activates EGFR in endothelial cells and reduces Sunitinib efficacy, and demonstrates that targeting this pathway enhances Sunitinib effectiveness.

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

This study analyzes monkeypox virus-host cell interactions using transcriptome data to identify signaling pathways, biomarkers, and potential drug candidates.

Modification Mechanism of Phenol-formaldehyde Resin with Crude Bio-oil by Model Compound Method

This study investigates how bio-oil components affect phenol-formaldehyde resin properties using model compounds, showing phenols and ketones improve synthesis while aldehydes and acids have negative effects, but all components enhance aging resistance.

Expanding adult tubular microvessels on stiff substrates with endothelial cells and pericytes from the same tissue

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

Genetic Variation and Disease Severity of Respiratory Syncytial Viruses

This study investigates the association between RSV genetic variations and disease severity in infants, finding significant links between phylogeny and specific protein variations in different subtypes.

Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

This paper describes a non-viral method for efficiently integrating large DNA into primary human T cells using CRISPR-Cas9 and homology-mediated end joining, achieving high functionality and anti-tumor activity.

Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian Influenza A subtypes among North American wild reservoir species

This study estimates interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild birds using genomic sequences, finding host diversity and ecology influence spread patterns.

CRISPR activation screening identifies VGLL3 and GATA2 as transcriptional regulators of PD-L1

The paper identifies VGLL3 and GATA2 as transcriptional regulators that upregulate PD-L1 expression through CRISPR activation screening and functional validation.

Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes

This study shows that RSV infection via CX3CR1 engagement induces Nucleolin and suppresses cilia-related genes, with CX3C motif mutation reversing these effects.

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

Increased Risk for Cerebral Small Vessel Disease is Associated with Quantitative Susceptibility Mapping in HIV Infected and Uninfected Individuals

This study finds that quantitative susceptibility mapping (QSM) correlates with cardiovascular risk factors and white matter hyperintensities in HIV-infected and uninfected individuals, suggesting QSM as an early marker of brain microcirculation changes.

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.