W. Wu

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain

The paper determines six structures of DosP, revealing how its heme-binding PAS domain regulates c-di-GMP phosphodiesterase activity through allosteric mechanisms.

High-yield production of recombinant human myelin oligodendrocyte glycoprotein in SHuffle bacteria without a refolding step

This paper describes a method to produce soluble recombinant human MOG in SHuffle bacteria without refolding, enabling B cell-dependent EAE studies.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

Brochosomes as an antireflective camouflage coating for leafhoppers

This study identifies brochosomes as an anti-reflective nano-coating in leafhoppers, revealing their structural proteins and evolutionary origin.

Single-shot water-fat imaging with multi-echo blip-rewound EPI

This paper develops a single-shot water-fat imaging technique using multi-echo blip-rewound EPI and Dixon-based post-processing, achieving faster and more robust separation of water and fat signals in MRI.

Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples

The paper develops a high-throughput method to measure single-cell density and applies it to study immune cell states and drug response in patient samples.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

Mechanisms mediating arylidene-indolinones induced degradation: thoughts on "Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype"

The paper discusses discrepancies in conclusions about arylidene-indolinones' mechanism of action, suggesting possible explanations for conflicting findings on their role as DCAF11 ligands and autophagy-tethering compounds.

Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretion

This study shows neurons enhance blood-brain barrier function by increasing claudin-5 and VE-cadherin via GDNF secretion and develops a triple co-culture model to predict BBB permeability.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

Diversity-disease relationships in natural microscopic nematode communities

This study examines diversity-disease relationships in wild nematode communities, finding that species-poor communities have higher microsporidia prevalence and immune activation.

Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a

The paper uses live-cell imaging to compare the target search efficiency of Cas9 and Cas12a variants, finding that LbdCas12a is faster and more efficient than SpydCas9.

Xanthomonas citri subsp. citri type III effector PthA4 directs the dynamical expression of a putative citrus carbohydrate-binding protein gene for canker formation

This study shows PthA4 induces CsLOB1, which in turn regulates Cs9g12620 expression, promoting citrus canker through dynamic gene regulation.

Role of C2-domain protein CAR1 in the plasma membrane ABA signaling response

This study investigates CAR1's role in PM-associated ABA signaling, showing ABA affects CAR1 dynamics and its ability to recruit HAB1 and SnRK2.2 to the PM.

Gene and protein sequence features augment HLA class I ligand predictions

The paper evaluates gene and protein sequence features as predictors of HLA class I ligand presentation, showing they improve predictions comparable to experimental gene expression data.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

The functional small RNA interactome of vancomycin tolerant Staphylococcus aureus

The paper identifies sRNAs mediating translational repression in vancomycin-tolerant S. aureus, with RsaOI regulating HPr and Atl under cell wall stress.

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

Direct quantification of unicellular algae sinking velocities reveals cell size, light, and nutrient-dependence

The paper quantifies sinking velocities of unicellular algae to show their dependence on cell size, light, and nutrients, revealing mechanisms linking cell composition to vertical movement.

A semiconductor 96-microplate platform for real-time impedance-based high-throughput screening

This paper introduces a semiconductor microplate platform for real-time impedance-based high-throughput screening, demonstrating its ability to profile compound mechanisms of action across diverse cell types.

Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA Binding Domains (2DBD-NRs)

This study identifies and classifies 2DBD-NRs across multiple animal phyla, proposes a nomenclature system, and shows their evolutionary history and conserved motifs.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.