Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis
A. G. Casanova, G. S. Roth, S. Hausmann, X. Lu, L. Belmudes, E. Bourova-Flin, N. M. Flores, A. M. Benitez, M. Caporicci, J. Vayr, S. Blanchet, F. Ielasi, S. Rousseaux, P. Hainaut, O. Gozani, , N. Reynoird
This study identifies SMYD2 as a master regulator of breast cancer metastasis and shows that targeting the SMYD2-BCAR3-FMNL axis can prevent metastatic spread.
bioRxiv · Sep 18, 2023Cancer Biology