ImmunologybioRxiv
Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
F. J. Lewis, D. Chatterjee, J. Kaczmarski…·I. A. Cockburn
The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.
DOI 10.1016/j.celrep.2021.108996