Y. Cai

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis

This study identifies DNM1 as a master regulator of EMT in ovarian cancer, showing it sustains the mesenchymal state through N-cadherin endocytic recycling and promotes metastasis.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State

The paper shows that inter-species mRNA transfer from mouse embryonic stem cells to human pluripotent stem cells reprograms them to a naive-like state through specific transcription factors.

Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses

This study shows that maternal IgA suppresses Enterobacteriaceae colonization and prevents the development of intestinal microbiota-specific CD4+ T cells in neonates.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer

The paper identifies a metabolic vulnerability in triple-negative breast cancer through sphingolipid metabolism, showing that targeting this pathway with eliglustat reduces tumor growth and improves survival.

The Interplay Between Nutrition and the Midgut Microbiome of the Mosquito Aedes aegypti Reveals Putative Symbionts.

This study examines how blood and sugar meals affect the midgut microbiome of Aedes aegypti, revealing shifts in microbial diversity and function over time.

Transcranial Photobiomodulation on the Left Prefrontal Cortex Enhances Mandarin Chinese L1 and L2 Complex Sentence Processing Performances

This study shows that transcranial photobiomodulation over the left prefrontal cortex improves sentence processing in Mandarin Chinese L1 and L2 speakers without affecting working memory.

Enhancing Light-Sheet Fluorescence Microscopy Illumination Beams through Deep Design Optimization

This paper optimizes light-sheet fluorescence microscopy illumination beams using deep learning to improve cell detection performance.

Comparing virtual staining artificial intelligence model performance on same-tissue versus serial-tissue sections based on CD3+ T-cell ground truth

This study compares a virtual staining AI model's performance on same-tissue versus serial-tissue sections using CD3+ T-cell ground truth, finding better performance with same-tissue data.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis.

This study shows that fatty acid metabolism in neutrophils worsens lung damage and bacterial replication in tuberculosis by promoting inflammation and neutrophil recruitment.

Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes

This study uses microfluidic impedance cytometry to analyze the cellular state changes in Hela cells treated with paclitaxel and vinblastine, showing distinct electrical parameter shifts during mitotic arrest and apoptosis.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits

The paper identifies and validates a six-gene regulatory circuit upstream of NLP6/7 in Arabidopsis and tomato, revealing conservation and divergence in nitrogen-responsive gene regulation across species.

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the tolerance mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy

The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

A common tolerance mechanism of bacterial biofilms to antibiotics

This study identifies a common mechanism by which bacterial biofilms resist antibiotics through lipid metabolism activation that reduces drug penetration and increases glucose consumption.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

Retinal axial motion analysis and implications for real-time correction in human retinal imaging

This study quantifies retinal axial motion using SDOCT and shows that a 1.2 kHz control loop achieves robust in-vivo retinal imaging.