A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
T. Shapira, I. A. Monreal, S. P. Dion, M. Jager, A. Desilets, A. D. Olmstead, T. Vandal, D. W. Buchholz, B. Imbiakha, G. Gao, A. Chin, W. D. Rees, T. Steiner, I. R. Nabi, E. Marsault, , F. Jean
This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.
bioRxiv · May 3, 2021 · PreprintMicrobiology