M. Jager

Isolation of Actinomyces cricetomyis sp. nov from orocervicofacial abscesses of African giant pouched rats (Cricetomys ansorgei)

The paper isolates and characterizes a novel Actinomyces species from abscesses in African giant pouched rats.

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

Accurate detection of circulating tumor DNA using nanopore consensus sequencing

This paper introduces CyclomicsSeq, a nanopore sequencing method that improves ctDNA detection sensitivity, enabling accurate TP53 mutation detection at 0.02% frequency in head-and-neck cancer patients.

Mutational impact of chronic alcohol use on stem cells in cirrhotic liver

This study investigates the mutational impact of chronic alcohol use on liver stem cells in cirrhotic livers and finds no alcohol-specific mutational signatures but identifies enriched oncogenic mutations in cancer genes.

The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle

This study presents the genome of Clytia hemisphaerica and analyzes transcriptomes across its life-cycle stages, revealing gene expression patterns and evolutionary insights into cnidarian development.

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

The paper investigates molecular responses to BRAF and EGFR inhibition in colorectal cancer cells, revealing metabolic shifts and MAPK pathway reactivation.