A. August

Th2 and Th17-Associated Immunopathology Following SARS-CoV-2 Breakthrough Infection in Spike-vaccinated ACE2-humanized Mice

This study investigates VAERD risks in vaccinated mice following SARS-CoV-2 breakthrough infections, revealing Th2/Th17-driven pulmonary immunopathology.

PTEN loss in glioma cell lines leads to increased extracellular vesicle biogenesis and PD-L1 cargo in a PI3K-dependent manner

This study shows PTEN loss increases EV biogenesis and PD-L1 cargo in glioma cells via PI3K signaling, enhancing immunosuppression.

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway

This study shows ITK signaling regulates the switch between Th17 and Treg cell lineages via a calcium-mediated pathway, with implications for modulating immune responses.

T cell development is regulated by high fidelity replication of mitochondrial DNA

This study shows that high fidelity mitochondrial DNA replication is essential for normal T cell development in the thymus, as reduced fidelity leads to premature thymocyte decline.

SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice

This study shows that eosinophils are not required for the development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice

This study examines the effects of PFOS exposure on immune cell development and function in mice, finding no significant suppression of immune responses or weight loss.

Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages

The paper shows that LAG3 and CD49b co-expression is not exclusive to Tr1 cells but also occurs in IL-10-producing Treg and CD8+ T cells under specific conditions.

TCR/ITK signaling via mTOR tunes CD8+ T cell homeostatic proliferation, metabolism, and anti-tumor effector function

The paper shows that ITK negatively regulates CD8+ T cell homeostatic proliferation, metabolism, and anti-tumor effector function through mTOR, challenging the notion that stronger TCR signals always enhance these processes.