EGFR-driven profibrotic signals in AKI-to-CKD transition are blocked by TNF inhibition: Opportunities for etanercept treatment
M. M. Abdelmageed, E. Kefaloyianni, A. Arthanarisami, F. Khamissi, J. J. Atkinson, A. Herrlich
This study shows that TNF inhibition with etanercept prevents AKI-to-CKD transition and fibrosis as effectively as EGFR inhibition in mice, suggesting TNF as a downstream effector of EGFR-driven profibrotic signals.
bioRxiv · Apr 29, 2021 · PreprintCell Biology