Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.
S. Bauherr, F. Larsberg, A. Petrich, H. S. Sperber, V. Klose, W. Azab, M. Schade, M. Luckner, C. T. Höfer, M. J. Lehmann, P. T. Witkowski, D. H. Krüger, A. Herrmann, R. Schwarzer
This study shows that Puumala virus uses both macropinocytosis and clathrin-mediated endocytosis for entry into mammalian cells, and inhibiting these pathways reduces infection.
bioRxiv · Jul 5, 2019Microbiology