A. Herrmann

P-BODY AND CYTOSKELETON REMODELING BY ORTHOHANTAVIRUSES.

This study uses advanced imaging to analyze how orthohantaviruses alter P-bodies and the cytoskeleton during infection, revealing spatial correlations and degradation patterns of viral RNAs.

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

The paper presents crystal structures of cathepsin L inhibitors and evaluates their antiviral activity against SARS-CoV-2.

The Chicken Chorioallantoic Membrane as a Low-Cost, High-Throughput Model for Cancer Imaging

This paper evaluates the chicken chorioallantoic membrane as a low-cost, high-throughput alternative to mouse models for cancer imaging using PET/CT.

A novel and highly specific Forssman antigen-binding protein from sheep polyomavirus

This paper identifies the Forssman glycolipid as a receptor for sheep polyomavirus and reports the first viral protein specifically binding to this antigen.

ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing

This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

Cell cycle dynamics and window of MUTE action during the terminal division of stomata and ramification of its loss-of-function on the cell cycle of an uncommitted precursor

This study investigates how MUTE regulates cell cycle dynamics during stomatal development in Arabidopsis, showing its role in upregulating cell cycle genes and controlling the transition from asymmetric to symmetric division.

Protein-based RBD-C-tag COVID-19 Vaccination Candidate Elicits Protection Activity against SARS-COV-2 Variant Infection

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

A Targeted Vaccine against COVID-19: S1-Fc Vaccine Targeting the Antigen-Presenting Cell Compartment Elicits Protection against SARS-CoV-2 Infection

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

A novel in-cell ELISA assay allows rapid and automated quantification of SARS-CoV-2 to analyse neutralizing antibodies and antiviral compounds

Characterization of fluorescent proteins with intramolecular photostabilization

This study screens covalently-linked photostabilizers on fluorescent proteins, finding that azobenzene derivatives significantly enhance photostability compared to other stabilizers.

UFMylation regulates translational homeostasis and cell cycle progression

This study shows UFMylation regulates translation and cell cycle progression by controlling eIF4F complex assembly and ribosome recruitment, independent of stress response pathways.

Analysing plasma membrane asymmetry of lipid organisation by fluorescence lifetime and correlation spectroscopy

The paper uses FLIM and ITIR-FCS to study lipid asymmetry in mammalian cell membranes, revealing distinct dynamics in the outer and inner leaflets.

Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.

This study shows that Puumala virus uses both macropinocytosis and clathrin-mediated endocytosis for entry into mammalian cells, and inhibiting these pathways reduces infection.

Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline

This study evaluates azaBINOL compounds as antiviral agents, identifying 7-isopropoxy-8-(naphth-1-yl)quinoline as a low-micromolar inhibitor of HIV-1 RNase H activity.

CDK inhibitors reduce cell proliferation and reverse hypoxia-induced metastasis of neuroblastoma tumours in a chick embryo model

On the impact of competing intra- and intermolecular triplet-state quenching on photobleaching and photoswitching kinetics of organic fluorophores

This study examines how intra- and intermolecular triplet-state quenching affects photobleaching and photoswitching in fluorophores, showing competition between these processes and identifying new roles for intramolecular quenchers.

Structural determinants of the interactions between Influenza A Virus Matrix protein M1 and lipid membranes

This study investigates the structural interactions of Influenza A Virus M1 protein with lipid membranes using experimental and theoretical methods, revealing details on membrane association, oligomerization, and structural changes upon binding.

Quantifying protein oligomerization in living cells: A systematic comparison of fluorescent proteins

This study compares fluorescent proteins for quantifying protein oligomerization using FCS and N&B measurements, finding that mCherry2 provides improved accuracy due to faster maturation.

Magnetic resonance imaging for characterization of a chick embryo model of cancer cell metastases

This study uses MRI with contrast agents to detect metastatic neuroblastoma in a chick embryo model, showing its effectiveness compared to fluorescence methods.

Could cyanobacteria have made the salinity transition during the late Archean?

This study examines how increasing salinity affects photosynthetic efficiency in two cyanobacteria, supporting their evolution from freshwater to saltier environments before the Great Oxygenation Event.