Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection
D. Hudrisier, D. Corral, A. Charton, M. Z. Krauss, E. Blanquart, F. Levillain, E. Lefrancais, T. Sneperger, J.-P. Girard, G. Eberl, Y. Poquet, J.-C. Guery, R. J. Arguello, M. R. Hepworth, O. Neyrolles
This study shows that Mycobacterium tuberculosis infection drives immature lung ILC2 to differentiate into ILC1-like cells through type 1 cytokines and a glycolytic program controlled by HIF1.
bioRxiv · Jan 19, 2021Immunology