A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3
S. Notova, F. Bonnardel, F. Rosato, L. Siukstaite, J. Schwaiger, N. Bovin, A. Varrot, W. Roemer, F. Lisacek, A. Imberty
The paper identifies a β-trefoil lectin from Salpingoeca rosetta that binds Gb3 and forms pores, leading to hemolysis and cancer cell toxicity.
bioRxiv · Feb 10, 2022 · PreprintBiochemistry