A. Imberty

The lectin LecB induces patches with basolateral characteristics at the apical membrane to promote Pseudomonas aeruginosa host cell invasion

This paper identifies LecB as a Pseudomonas aeruginosa lectin that triggers PI3K signaling and caveolin-1 recruitment at the apical membrane to promote host cell invasion.

A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3

The paper identifies a β-trefoil lectin from Salpingoeca rosetta that binds Gb3 and forms pores, leading to hemolysis and cancer cell toxicity.

Neutron crystallography reveals novel mechanisms used by Pseudomonas aeruginosa for host-cell binding

The paper uses neutron crystallography to study the binding mechanism of Pseudomonas aeruginosa's LecB lectin to fucose, revealing structural features that contribute to high-affinity binding.

The Pseudomonas aeruginosa lectin LecB causes integrin internalization to facilitate crawling of bacteria underneath host cells

This paper shows that Pseudomonas aeruginosa's LecB lectin binds integrins and causes their internalization, enabling bacterial crawling under host cells.

Induction of Rare Conformation of Oligosaccharide by Binding to Calcium-dependent Bacterial Lectin: X-ray Crystallography and Modelling Study

The paper uses X-ray crystallography and theoretical chemistry to study how a bacterial lectin stabilizes an unusual oligosaccharide conformation, with implications for designing carbohydrate-based drugs.