Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus
K. H. Tisthammer, C. Solis, F. Oracles, M. Nzerem, R. Winstead, W. Dong, J. B. Joy, P. S. Pennings
This study estimates in vivo fitness costs of HCV mutations using frequency-based analysis across 195 patients, revealing mutation type and genomic location effects on fitness costs.
bioRxiv · Oct 1, 2020Evolutionary Biology