Evolutionary BiologybioRxiv
Assessing in vivo mutation frequencies and creating a high-resolution genome-wide map of fitness costs of Hepatitis C virus
K. H. Tisthammer, C. Solis, F. Oracles…·P. S. Pennings
This study estimates in vivo fitness costs of HCV mutations using frequency-based analysis across 195 patients, revealing mutation type and genomic location effects on fitness costs.
DOI 10.1371/journal.pgen.1010179