Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1alpha axis plays a key role in host resistance to Plasmodium infection
K. C. Matteucci, N. P. d. S. Leite, P. A. Assis, I. C. Hirako, F. Pioto, O. OJELABI, J. E. TOLLER-KAWAHISA, L. G. Vaz, D. L. Costa, J. S. Silva, J. C. Alves-Filho, R. Gazzinelli
The paper shows that the TNF-iNOS-HIF-1alpha axis drives glycolysis in monocytes, enhancing host resistance to Plasmodium infection and sickness behavior.
bioRxiv · Mar 26, 2024Immunology