Author

D. L. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Sher· 2 shared C. A. Grace· 2 shared D. C. Jeffares· 2 shared S. Forrester· 2 shared A. Aare· 1 shared A. Garcia· 1 shared A. L. V. Zorzetto-Fernandes· 1 shared A. Sardinha-Silva· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Sher

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1alpha axis plays a key role in host resistance to Plasmodium infection

K. C. Matteucci, N. P. d. S. Leite, P. A. Assis, I. C. Hirako, F. Pioto, O. OJELABI, J. E. TOLLER-KAWAHISA, L. G. Vaz, D. L. Costa, J. S. Silva, J. C. Alves-Filho, R. Gazzinelli

The paper shows that the TNF-iNOS-HIF-1alpha axis drives glycolysis in monocytes, enhancing host resistance to Plasmodium infection and sickness behavior.

bioRxiv · Mar 26, 2024Immunology

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

J. Ruelas Castillo, P. Neupane, S. Karanika, S. Krug, D. Quijada, A. Garcia, S. Ayeh, A. Yilma, D. L. Costa, A. Sher, N. Fotouhi, N. Serbina, P. C. Karakousis

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

bioRxiv · Aug 9, 2023Microbiology

Parasite genotype is a major predictor of mortality from visceral leishmaniasis

C. A. Grace, K. S. Sousa Carvalho, M. I. Sousa Lima, V. Costa Silva, J. L. Reis-Cunha, M. J. Brune, S. Forrester, C. d. M. Pedrozo e Silva de Azevedo, D. L. Costa, D. Speed, J. Mottram, D. C. Jeffares, C. H. N. Costa

This study identifies parasite genotype as a major predictor of mortality from visceral leishmaniasis in Brazil, with heritability estimates up to 83% for mortality.

bioRxiv · Jul 28, 2022Evolutionary Biology

Multiple targets of balancing selection in Leishmania donovani complex parasites

C. A. Grace, S. Forrester, V. C. Silva, A. Aare, H. Kilford, Y. P. Chew, S. James, D. L. Costa, J. C. Mottram, C. C. H. N. Costa, D. C. Jeffares

This study identifies five genetically distinct populations in Leishmania donovani complex parasites and finds balancing selection signals not shared between populations, highlighting 19 candidate genes.

bioRxiv · Mar 2, 2021 · PreprintEvolutionary Biology

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

A. Sardinha-Silva, F. C. Mendonca-Natividade, C. F. Pinzan, C. D. Lopes, D. L. Costa, D. Jacot, F. F. Fernandes, A. L. V. Zorzetto-Fernandes, N. J. Gay, A. Sher, D. Jankovic, D. Soldati-Favre, M. E. Grigg, M. C. Roque-Barreira

This paper shows that Toxoplasma gondii microneme proteins MIC1 and MIC4 bind TLR2 and TLR4 N-glycans to activate innate immune responses and regulate infection outcomes.

bioRxiv · Jun 13, 2019Immunology