Unblocking genome editing of major animal mycoplasmas using CRISPR/Cas9 base editor systems
T. Ipoutcha, F. Rideau, G. Gourgues, Y. Arfi, C. Lartigue, A. Blanchard, P. Sirand-Pugnet
This paper develops a CRISPR/Cas9 base editor system to efficiently edit the genomes of three major mycoplasma pathogens, enabling the study of virulence factors and vaccine development.
bioRxiv · Mar 9, 2022 · PreprintMicrobiology