Generation of inducible SMARCAL1 knock-down iPSC to model severe Schimke immune-osseous dysplasia reveals a link between replication stress and altered expression of master differentiation genes
G. M. Pugliese, F. Salaris, V. Palermo, V. Marabitti, N. Morina, A. Rosa, A. Franchitto, P. Pichierri
This study generates SMARCAL1 knock-down iPSCs to model Schimke immune-osseous dysplasia, revealing replication stress and altered gene expression as key factors in disease pathogenesis.
bioRxiv · Feb 10, 2019Cell Biology