G. M. Pugliese

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

This study shows that phosphorylation status of MUS81 affects PARPi sensitivity in BRCA2-deficient cells by modulating MUS81 activity in different phases of the cell cycle.

The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.

This study generates SMARCAL1 knock-down iPSCs to model Schimke immune-osseous dysplasia, revealing replication stress and altered gene expression as key factors in disease pathogenesis.

This study shows CK2 phosphorylates MUS81 at Serine 87 in mitosis and under replication stress, promoting its interaction with SLX4 and affecting chromosome stability.