Connexin 43 confers chemoresistance through activating PI3K
K. Pridham, F. Shah, K. Sheng, S. Guo, M. Liu, P. Kanabur, S. Lamouille, G. Lewis, M. Morales, J. Jourdan, C. Grek, G. Ghatnekar, R. Varghese, D. Kelly, R. G. Gourdie, Z. Sheng
This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.
bioRxiv · Oct 14, 2020Cancer Biology