SiglecFhigh neutrophils in lung tumor tissues suppress local CD8 T cell responses and limit the efficacy of anti PD-L1 antibodies
F. Simoncello, G. M. Piperno, N. Caronni, T. Battini, A. Cappelletto, S. Bicciato, F. Benvenuti
This study shows that SiglecFhigh neutrophils in lung tumors suppress CD8 T cell responses and reduce the effectiveness of anti-PD-L1 therapy.
bioRxiv · Oct 21, 2021 · PreprintImmunology