A P2rx7 passenger mutation affects the vitality and function of immune cells in P2X4ko and other transgenic mice
M. Er-Lukowiak, Y. Duan, F. Rassendren, L. Ulmann, A. Nicke, F. Ufer, M. A. Friese, F. Koch-Nolte, T. Magnus, B. Rissiek
The paper identifies a P2rx7 passenger mutation in 129-derived transgenic mice that affects T cell vitality and function, increasing sensitivity to NAD-induced cell death.
bioRxiv · Jun 10, 2020 · PreprintImmunology