Y. Duan

Global invasion history and genomic signatures of adaptation of a highly invasive lace bug

This study investigates the genomic basis of invasion in the sycamore lace bug, identifying adaptation signatures and invasion routes through genomic analysis.

Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase

The paper identifies and characterizes the chm biosynthetic gene cluster responsible for chalkophomycin production in Streptomyces sp. CB00271 and proposes a biosynthesis model based on sequence analysis and structural modeling.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

CDC5L surveils cellular stress responses and stress granule formation through transcriptional repression

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Computational exploration of the global microbiome for antibiotic discovery

The paper uses machine learning to predict antimicrobial peptides from microbiome data, identifies novel peptides, and validates their antibacterial activity against drug-resistant pathogens.

DNA Origami Tension Sensors (DOTS) to study T cell receptor mechanics at membrane junctions

This study develops DNA origami tension sensors (DOTS) to measure TCR mechanotransduction at immune cell junctions, revealing forces between 5-10 pN and dependencies on cell state and antigen properties.

Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization

This paper characterizes YisK in Bacillus subtilis, showing it has oxaloacetate decarboxylase activity and Mbl-dependent localization.

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

Mechano-Cas12a Assisted Tension Sensor (MCATS) for Massively Amplified Cell Traction Force Measurements

MCATS detects cell-generated forces using CRISPR-Cas12a, showing drug effects on platelet forces and identifying platelet dysfunction after cardiopulmonary bypass.

Crystal structure of monkeypox H1 phosphatase, an Antiviral Drug Target

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages

This study shows that the LRR domain of NLRP3 is essential for its inflammasome activation in macrophages by enabling self-association, oligomerization, and interaction with NEK7.

Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

Lysine acetylation regulates antibiotic resistance in Escherichia coli

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

Editing the CsDMR6 Gene in Citrus Results in Resistance to the Bacterial Disease Citrus Canker

This study edits the CsDMR6 gene in citrus to confer resistance to citrus canker, showing significant reduction in disease symptoms and bacterial population.

A chromosome-level phased Citrus sinensis genome facilitates understanding Huanglongbing tolerance mechanisms at the allelic level in an irradiation induced mutant

The paper presents a chromosome-level phased genome of Valencia sweet orange, enabling allelic-level analysis of Huanglongbing tolerance in mutants.

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

Soil microbial community responses to short-term nitrogen addition in Chinas Horqin Sandy Land

This study investigates the effects of short-term nitrogen addition on soil microbial communities in two types of sandy lands, finding no significant changes in microbial biomass or microflora but increased β-glucosidase activity in some treatments.

A P2rx7 passenger mutation affects the vitality and function of immune cells in P2X4ko and other transgenic mice

The paper identifies a P2rx7 passenger mutation in 129-derived transgenic mice that affects T cell vitality and function, increasing sensitivity to NAD-induced cell death.

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

Visual function restoration in genetically blind mice via endogenous cellular reprogramming

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals during COVID-19 Outbreak

The paper measures SARS-CoV-2 RNA concentration in aerosols from different areas of Wuhan hospitals during the COVID-19 outbreak and finds that aerosol transmission is possible under certain conditions.

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

A-to-I RNA editing in honeybees shows signals of adaptation and convergent evolution

This study identifies A-to-I RNA editing sites in honeybees, showing adaptation and convergent evolution across species.

Global gene expression profile during low temperature in the brain of grass carp (Ctenopharyngodon idellus)

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.

Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance

This study identifies small molecules that induce cellular stress resistance against paraquat, cadmium, and methyl methanesulfonate, with some compounds activating Nrf2 signaling and others triggering inflammatory and AMPK pathways.

Carbendazim-resistance associated β2-tubulin substitutions increase deoxynivalenol biosynthesis by reducing the interaction between β2-tubulin and IDH3 in Fusarium graminearum

The paper shows that β2-tubulin substitutions linked to carbendazim resistance in Fusarium graminearum reduce its interaction with IDH3, leading to increased DON biosynthesis by decreasing IDH3 expression and acetyl-CoA accumulation.