Serine 165 Phosphorylation of SHARPIN regulates the Activation of NF-κB
A. Thys, K. Trillet, S. Rosinska, A. Gayraud, T. Douanne, Y. Danger, C. Renaud, L. Antigny, R. Lavigne, C. Pineau, E. Com, F. Verite, J. Gavard, N. Bidere
The paper shows that phosphorylation of SHARPIN at serine 165 is required for optimal NF-κB activation, despite not affecting linear ubiquitin chain formation.
bioRxiv · Jul 2, 2020Immunology