PTEN and ARID1A haploinsufficiency equip colonic epithelium for oncogenic transformation
N. Skoufou-Papoutsaki, S. Adler, S. Mehmed, C. Tume, C. Olpe, E. Morrissey, R. Kemp, A.-C. Girard, E. B. Moutin, C. S. R. Chilamakuri, J. L. Miller, C. Lindskog, F. Werle, K. Marks, F. Perrone, , D. J. Winton
The paper investigates how PTEN and ARID1A haploinsufficiency in colonic epithelium contributes to oncogenic transformation by altering clone dynamics and creating a pro-tumorigenic microenvironment.
bioRxiv · Mar 27, 2024 · PreprintCancer Biology