Author

F. Perrone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. Zilbauer· 3 shared D. J. Winton· 2 shared K. Nayak· 2 shared N. Skoufou-Papoutsaki· 2 shared R. Kemp· 2 shared S. Adler· 2 shared S. Mehmed· 2 shared A. Fleming· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

M. Zilbauer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PTEN and ARID1A haploinsufficiency equip colonic epithelium for oncogenic transformation

N. Skoufou-Papoutsaki, S. Adler, S. Mehmed, C. Tume, C. Olpe, E. Morrissey, R. Kemp, A.-C. Girard, E. B. Moutin, C. S. R. Chilamakuri, J. L. Miller, C. Lindskog, F. Werle, K. Marks, F. Perrone, , D. J. Winton

The paper investigates how PTEN and ARID1A haploinsufficiency in colonic epithelium contributes to oncogenic transformation by altering clone dynamics and creating a pro-tumorigenic microenvironment.

bioRxiv · Mar 27, 2024 · PreprintCancer Biology

B cell maturation restored ancestral germlines to control Omicron BA.2.86

I. Paciello, G. Pierleoni, E. Pantano, G. Antonelli, P. Pileri, G. Maccari, D. Cardamone, G. Realini, F. Perrone, M. M. Neto, S. Pozzessere, M. Fabbiani, F. Panza, I. Rancan, M. Tumbarello, , E. Andreano

The paper analyzes neutralizing antibodies from vaccinated and hybrid immune individuals to show that restored B cell germlines enhance neutralization against SARS-CoV-2 variants like BA.2.86.

bioRxiv · Mar 3, 2024 · PreprintImmunology

Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR

N. Skoufou-Papoutsaki, S. Adler, P. D'Santos, L. Mannion, S. Mehmed, R. Kemp, A. Smith, F. Perrone, K. Nayak, A. Russell, M. Zilbauer, D. J. Winton

This study develops an efficient ribonucleoprotein-based CRISPR method for editing human intestinal organoids, achieving 98% editing efficiency with no off-target effects and revealing PTEN loss phenotypes.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

Cells of the human intestinal tract mapped across space and time

R. Elmentaite, N. Kumasaka, H. W. King, K. Roberts, M. Dabrowska, S. Pritchard, L. Bolt, S. F. Vieira, L. Mamanova, N. Huang, I. Goh Kai'En, E. Stephenson, J. Engelbert, R. A. Botting, A. Fleming, , S. A. Teichmann

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

bioRxiv · Apr 7, 2021Cell Biology