Fabio Zanini

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.

Error rates, PCR recombination, and sampling depth in HIV-1 Whole Genome Deep Sequencing

This study evaluates error rates, PCR recombination, and sampling depth in HIV-1 whole genome deep sequencing, finding rare mutations down to 0.2% can be detected.

In-vivo mutation rates and fitness landscape of HIV-1

The paper estimates mutation rates and fitness costs of HIV-1 mutations using longitudinal sequencing data, finding universal fitness landscape patterns across patients.

Establishment and stability of the latent HIV-1 DNA reservoir

The paper analyzes HIV-1 DNA reservoirs during suppressive ART and finds that most viral DNA sequences are similar to pre-treatment RNA sequences, suggesting ART halts viral turnover rather than persistent replication.