Nicholas Schaum

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

This study develops cell type-specific aging clocks using single-cell transcriptomic data to quantify aging and rejuvenation in the brain's neurogenic regions.

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

Undulating changes in human plasma proteome across lifespan are linked to disease

Profiling 2,925 plasma proteins in 4,331 people aged 18-95 reveals non-linear aging: protein waves crest at 34, 60 and 78 years, later waves overlapping disease proteomes.

The murine transcriptome reveals global aging nodes with organ-specific phase and amplitude

The paper analyzes aging dynamics across 17 organs and plasma proteomics in mice, revealing consistent gene expression trajectories with organ-specific timing and amplitude.

Brain endothelial cells are exquisite sensors of age-related circulatory cues

This study uses single-cell RNA sequencing to show that brain endothelial cells respond to circulatory cues of aging, with aged plasma inducing aging transcriptomes and young plasma reversing them.

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

The paper creates a single-cell transcriptomic atlas of 20 mouse organs and tissues, providing a resource for studying gene expression across cell types.