Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)
Paige J. Monsen, Prashant V. Bommi, Arabela A. Grigorescu, Kristen L. Lauing, Yingyu Mao, Payton Berardi, Lijie Zhai, Ohiowele Ojo, Manon Penco-Campillo, Taylor Koch, Michael Egozi, Sonam Jha, Sara F. Dunne, Hong Jiang, Guiqin Song, , Gary E. Schiltz
This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.
Journal of Medicinal Chemistry · Feb 13, 2025Peer-reviewedBiochemistry