Author

Arabela A. Grigorescu

Northwestern UniversityORCID 0000-0003-0429-8994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ali Vaziri GohariD· 1 shared Amit RahiiD· 1 shared Bakhtiar YaminiiD· 1 shared Derek Alan WainwrightiD· 1 shared Dileep VarmaiD· 1 shared Fang Zhang· 1 shared Gary E. SchiltziD· 1 shared Guiqin SongiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Ali Vaziri GoharORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedFeb 13, 2025

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)

Paige J. Monsen, Prashant V. Bommi, Arabela A. Grigorescu…·Gary E. Schiltz

This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.

27 citationstop 1%

humanexperimental assay

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BiophysicsCytoskeletonPeer-reviewedNov 6, 2024

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi…·Dileep Varma

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

2 citations

humanexperimental assay

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