Targeting IL-2 to inflamed tissues via oxidation-specific epitopes enables third-generation bispecific IL-2 therapeutics
Thomas Vazquez, Monica Cuevas-martinez, Nicolas Billiald, Florentina Porsch, Marie Sion, Fatima Saddouk, Céline Albalaa, Lorena Zentilin, Lauri Peil, Joan Teyra, Tahar Bouceba, Inès Leleu, Sylviane Pied, Mart Ustav, Alain Tedgui, , David Klatzmann
This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.
bioRxiv · Sep 15, 2026 · PreprintImmunology