David Klatzmann

The paper identifies a shared Treg dysfunction signature across rheumatic diseases, suggesting a therapeutic window of opportunity for Treg-targeted treatments.

This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.

The paper identifies sex-specific differences in TCR selection during thymic development, showing female effector T cells have more autoimmunity-associated TCRs while female Tregs have fewer.

The paper develops a gene signature to distinguish type 1 diabetic patients from healthy donors using whole blood transcriptomic data, finding that combining multiple analytical methods improves classification accuracy.

This study identifies Treg dysfunction as associated with OA-related pain through multi-omic analysis of peripheral blood from knee OA patients.

The paper benchmarks nine unsupervised methods for inferring TCR specificity using a curated database of 190,670 human TCRs, identifying method-specific strengths in retention, purity, and sensitivity.

AnalyzAIRR provides a user-friendly R package for analyzing bulk AIRR sequencing data, enabling comprehensive immune system analysis through advanced statistical and visualization tools.

This study shows IL-1β signaling affects Tfh and Tfr cells in human lymphoid tissues, linking it to autoantibody production and autoimmune disease.

Maternal immune activation causes Treg deficiency in offspring, leading to brain inflammation and autism-like behaviors, which can be reversed by Treg stimulation.

This study shows that IL-1R2 on Tfr cells prevents excessive activation and allergy by limiting IgE and promoting IgG responses.

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

The paper identifies uterine tissue-resident regulatory T cells (uTregs) that support fetal growth by promoting uterine remodeling and vascular development during pregnancy.

This study analyzes Tfr and Tfh cell TCR repertoires to show their antigen specificity and reveals bystander activation of follicular T cells during immune responses.

The paper identifies hypomethylation patterns in early placenta similar to solid tumors, linking them to genes involved in EMT, immune response, and inflammation.