Embryonic Atrial Injury Programs an Anti-Fibrotic Atrial Fibrillation Substrate
Fei Xin, Hua Wang, Xinyi Zhao, Xinhui Xu, Jiaheng Cao, Kaiyue Zhang, Yuanyuan Zhang, Jingjing Tian, Yangyang Jia, Changye Sun, Yinming Liang, Xiongwen Chen, Jikui Wang
This study shows that embryonic atrial injury leads to anti-fibrotic changes in adult atria through GPNMB-mediated mechanisms, preventing fibrosis.
bioRxiv · Sep 16, 2025 · PreprintPathology