Acidic microenvironment shaped by lactate accumulation promotes pluripotency through multiple mechanisms
Wenting Guo, Shaohua Wang, Xiaoshan Zhang, Ming Shi, Jing Hao, Xiwen Wang, Kaili Gu, Feifei Duan, Ying Yan, Xi Yang, Chao Zhang, Le‐Qi Liao, Yangming Wang
This study shows that an acidic microenvironment, caused by lactate accumulation, promotes pluripotency in mouse and human ESCs through multiple mechanisms involving histone modification, mRNA stability, and microRNA regulation.
bioRxiv · Mar 15, 2018 · PreprintDevelopmental Biology